Description

1-Fluoro-2,5-Dimethyl-4-Nitrobenzene is a strategically important fluorinated aromatic intermediate. This compound matters for its role as a versatile building block in advanced organic synthesis, enabling the introduction of fluorine and nitro functional groups into complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated aromatic units.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized nitro- and fluoro-substituted dyes and colorants.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and constructing complex, multi-functionalized benzene derivatives in academic and industrial labs.

Basic Information

Product Name	1-Fluoro-2,5-Dimethyl-4-Nitrobenzene
CAS No.	1736-88-5
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	4-Nitro-2,5-dimethylfluorobenzene; 2,5-Dimethyl-4-nitrofluorobenzene; 1-Fluoro-2,5-dimethyl-4-nitrobenzene; 2-Fluoro-1,4-dimethyl-5-nitrobenzene; 4-Fluoro-2,5-dimethylnitrobenzene; 2,5-Dimethyl-1-fluoro-4-nitrobenzene; NSC 406903; F246
EINECS	217-089-4

Quality Control

Our 1-Fluoro-2,5-Dimethyl-4-Nitrobenzene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	65 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.