Description

1-Fluoro-2-Nitrobenzene is a versatile aromatic nitro compound distinguished by its fluorine substituent, making it a valuable building block in advanced organic synthesis. Its primary commercial value lies in its dual functional groups, which allow for selective chemical transformations and the introduction of fluorine into complex molecular architectures. This intermediate is essential for manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create active ingredients, dyes, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluoroquinolone antibiotics and other active pharmaceutical ingredients (APIs) containing a fluorinated aromatic ring.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and stability.
• Dye and Pigment Manufacturing: Serves as an intermediate for producing azo dyes and other complex colorants.
• Organic Synthesis Building Block: Employed in nucleophilic aromatic substitution reactions and as a starting material for synthesizing fluorinated anilines and benzimidazoles.
• Material Science Research: Used in academic and industrial R&D for developing novel fluorinated polymers and liquid crystals.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki and Buchwald-Hartwig amination for creating biaryl structures.

Basic Information

Product Name	1-Fluoro-2-Nitrobenzene
CAS No.	1493-27-2
Molecular Formula	C6H4FNO2
Molecular Weight	141.10 g/mol
Synonyms	2-Fluoronitrobenzene; o-Fluoronitrobenzene; 1-Fluoro-2-nitrobenzene; 2-Nitrofluorobenzene; ortho-Fluoronitrobenzene; Fluoronitrobenzene; NSC 8766; Benzene, 1-fluoro-2-nitro-
EINECS	216-081-1

Quality Control

Our 1-Fluoro-2-Nitrobenzene is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of industrial and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Clear, pale yellow to yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.33 g/cm³
Boiling Point	~205-207 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.