Description

4-Chloro-3-Nitrobenzotrifluoride is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both electron-withdrawing nitro and trifluoromethyl groups adjacent to a reactive chlorine atom, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a substituted benzotrifluoride scaffold for enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides, where the trifluoromethyl group often contributes to biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Employed in the production of specialized dyes and pigments, leveraging the nitro group for color development and the halogen for further chemical modifications.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations, enabling the creation of diverse biaryl structures.
• Organic Synthesis Building Block: Provides a multifunctional platform for nucleophilic aromatic substitution (SNAr) and reduction reactions to generate a variety of aniline and diamino derivatives.

Basic Information

Product Name	4-Chloro-3-Nitrobenzotrifluoride
CAS No.	121-17-5
Molecular Formula	C7H3ClF3NO2
Molecular Weight	225.55 g/mol
Synonyms	1-Chloro-4-(trifluoromethyl)-2-nitrobenzene; 3-Nitro-4-chlorobenzotrifluoride; 4-Chloro-α,α,α-trifluoro-3-nitrotoluene; 2-Nitro-4-chlorobenzotrifluoride; 4-Chloro-3-nitro-α,α,α-trifluorotoluene; Benzene, 1-chloro-4-(trifluoromethyl)-2-nitro-; PCBTF-NO2
EINECS	204-453-7

Quality Control

Our 4-Chloro-3-Nitrobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and reducing agents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40°C - 44°C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.