Description

4-(Difluoromethoxy)Nitrobenzene is a high-purity fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique difluoromethoxy-nitrobenzene structure makes it a versatile building block for introducing fluorine-containing motifs into target molecules, which is critical for modulating the physical, chemical, and biological properties of final products. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic ether groups to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve efficacy and environmental profile.
• Liquid Crystal & Electronic Materials: Serves as a building block for fluorinated components in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs) due to its influence on dielectric constant and molecular alignment.
• Organic Synthesis & Chemical Research: Employed as a specialized reagent in cross-coupling reactions, nucleophilic aromatic substitutions, and other transformations to create complex fluorinated compounds for material science.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing novel fluorinated dyes and pigments with enhanced lightfastness and unique chromatic properties.

Basic Information

Product Name	4-(Difluoromethoxy)Nitrobenzene
CAS No.	1544-86-1
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	1-Nitro-4-(difluoromethoxy)benzene; p-(Difluoromethoxy)nitrobenzene; 4-Nitrophenyl difluoromethyl ether; Difluoromethoxybenzene, 4-nitro-; Benzene, 1-(difluoromethoxy)-4-nitro-; NSC 406916; α,α-Difluoro-4-nitroanisole
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, reducing agents, and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Max. Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.