Description

2-(Trifluoromethoxy)Nitrobenzene is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique molecular structure, featuring both a nitro group and a trifluoromethoxy substituent, makes it a critical building block for creating complex, high-value compounds. This product is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries seeking to introduce fluorine-containing motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring the trifluoromethoxy pharmacophore to enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved pesticidal activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in advanced display technologies.
• Organic Electronics: Employed in the research and production of materials for organic light-emitting diodes (OLEDs) and semiconductors, leveraging its electron-withdrawing properties.
• Dye and Pigment Industry: Acts as an intermediate for synthesizing specialized dyes and pigments with unique color fastness and chemical resistance properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl systems.

Basic Information

Product Name	2-(Trifluoromethoxy)Nitrobenzene
CAS No.	1644-88-8
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	1-Nitro-2-(trifluoromethoxy)benzene; 2-Nitro-α,α,α-trifluoroanisole; o-(Trifluoromethoxy)nitrobenzene; 2-Nitrophenyl trifluoromethyl ether; 2-Trifluoromethoxynitrobenzene; Nitro-2-trifluoromethoxybenzene; Benzene, 1-nitro-2-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.