Description

2,4-Difluoro-5-Chloronitrobenzene is a high-value halogenated nitrobenzene derivative serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an essential intermediate for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by R&D chemists and process development scientists for constructing active pharmaceutical ingredients (APIs), crop protection agents, and specialty dyes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated and chlorinated active pharmaceutical ingredients (APIs), including antibacterial and antifungal agents.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides, leveraging the bioactivity of its halogen and nitro functional groups.
• Material Science: Used in the research and production of advanced polymers, liquid crystals, and electronic materials requiring specific aromatic fluorination.
• Dye & Pigment Manufacturing: Intermediate for synthesizing complex, color-fast azo dyes and specialty pigments.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Organic Synthesis Research: A versatile reagent in academic and industrial laboratories for exploring novel nucleophilic aromatic substitution (SNAr) pathways and heterocycle formation.

Basic Information

Item	Details
Product Name	2,4-Difluoro-5-Chloronitrobenzene
CAS No.	1481-68-1
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	5-Chloro-2,4-difluoronitrobenzene; 1-Chloro-2,4-difluoro-5-nitrobenzene; 2,4-Difluoro-5-nitrochlorobenzene; 5-Nitro-2,4-difluorochlorobenzene; 2,4-Difluoro-1-chloro-5-nitrobenzene; NSC 403108; 1481-68-1
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-5-Chloronitrobenzene is manufactured under strict quality management protocols. We ensure compliance with relevant industry standards through rigorous in-process and final release testing, including identity confirmation, purity assay, and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent degradation.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.