Description

1-Chloro-2-(1,1,2,2-Tetrafluoroethoxy)Benzene is a specialized fluorinated aromatic ether building block of significant interest in advanced chemical synthesis. Its core value lies in the unique combination of a reactive chlorobenzene moiety with a highly stable tetrafluoroethoxy substituent, enabling precise molecular modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require high-purity intermediates to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated side chains to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorinated ether group can enhance biological activity and environmental persistence.
• Liquid Crystal & Electronic Chemicals: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds and dielectric fluids for high-performance electronic applications.
• Polymer & Material Science: Acts as a monomer or modifier in the creation of specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce complex fluorinated aromatic structures.

Basic Information

Product Name	1-Chloro-2-(1,1,2,2-Tetrafluoroethoxy)Benzene
CAS No.	957372-65-5
Molecular Formula	C8H5ClF4O
Molecular Weight	228.57 g/mol
Synonyms	2-Chloro-1-(1,1,2,2-tetrafluoroethoxy)benzene; 1-Chloro-2-(tetrafluoroethoxy)benzene; o-Chlorotetrafluoroethoxybenzene; Benzene, 1-chloro-2-(1,1,2,2-tetrafluoroethoxy)-; 2-(1,1,2,2-Tetrafluoroethoxy)chlorobenzene; 957372-65-5 (CAS Name)
EINECS	Contact for details

Quality Control

Every batch of 1-Chloro-2-(1,1,2,2-Tetrafluoroethoxy)Benzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and sources of ignition. Due to the presence of fluoride, ensure containers are properly sealed and compatible with the material.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.