Description

(2S,3R,4S,5R)-5-((Benzyloxy)Methyl)-4-Fluoro-2-Methoxytetrahydrofuran-3-Ol is a high-purity, fluorinated carbohydrate derivative that serves as a critical chiral building block in advanced organic synthesis. Its precise stereochemistry and functional groups make it an invaluable intermediate for constructing complex bioactive molecules with high enantiomeric purity. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of nucleoside analogs, antiviral agents, and other fine chemicals where fluorination is a key structural modification.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel antiviral and anticancer nucleoside analogs.
• Probe & Diagnostic Development: Used in the synthesis of fluorinated probes for Positron Emission Tomography (PET) imaging and other diagnostic applications.
• Glycochemistry Research: A valuable substrate for studying fluorinated sugar chemistry, enzyme inhibition, and metabolic pathways.
• Process Chemistry: Employed in route scouting and scale-up for the production of fluorinated active pharmaceutical ingredients (APIs).
• Academic & Industrial R&D: Serves as a reference standard and building block in medicinal chemistry and chemical biology programs.

Basic Information

Item	Details
Product Name	(2S,3R,4S,5R)-5-((Benzyloxy)Methyl)-4-Fluoro-2-Methoxytetrahydrofuran-3-Ol
CAS No.	14980-09-7
Molecular Formula	C13H17FO4
Molecular Weight	256.27 g/mol
Synonyms	4-Fluoro-5-O-benzyl-2,3-O-isopropylidene-D-ribofuranose; 1-O-Benzyl-4-fluoro-2,3-O-isopropylidene-D-ribitol; 4-Fluoro-2,3-O-isopropylidene-5-O-benzyl-D-ribofuranose; Benzyl 4-fluoro-2,3-O-isopropylidene-D-ribofuranoside; Fluorinated ribofuranose derivative; D-Ribofuranose, 5-O-benzyl-4-fluoro-2,3-O-(1-methylethylidene)-; 14980-09-7
EINECS	Contact for details

Quality Control

Every batch of (2S,3R,4S,5R)-5-((Benzyloxy)Methyl)-4-Fluoro-2-Methoxytetrahydrofuran-3-Ol is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure compliance with research and development grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral purity is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.