Description

6-Fluoroquinazolin-4-One is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its role as a versatile precursor for the development of novel pharmaceutical compounds and agrochemicals, particularly those targeting kinase inhibition. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for their synthetic pipelines. The CAS number for this specific compound is 16499-56-2.

Application

6-Fluoroquinazolin-4-One serves as a critical synthetic intermediate in several high-value industrial and research domains:

• Pharmaceutical Intermediate: A key building block for the synthesis of tyrosine kinase inhibitors (TKIs) and other targeted therapeutic agents.
• Agrochemical Research: Used in developing novel herbicides and fungicides, leveraging the bioactivity of the quinazolinone scaffold.
• Fine Chemical Synthesis: Employed in the preparation of complex fluorinated organic molecules for material science and specialty chemistry applications.
• Academic & R&D: A valuable compound for medicinal chemistry research, structure-activity relationship (SAR) studies, and new reaction methodology development.

Basic Information

Product Name	6-Fluoroquinazolin-4-One
CAS No.	16499-56-2
Molecular Formula	C₈H₅FN₂O
Molecular Weight	164.14 g/mol
Synonyms	6-Fluoro-4(3H)-quinazolinone; 6-Fluoro-4-hydroxyquinazoline; 6-Fluoroquinazolin-4(3H)-one; 4(3H)-Quinazolinone, 6-fluoro-; 6-Fluoro-3,4-dihydro-4-oxoquinazoline; 6-Fluoro-4-oxo-3,4-dihydroquinazoline
EINECS	Contact for details

Quality Control

Our 6-Fluoroquinazolin-4-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.