Description

1-[4,8-bis-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-yl]-2,2,2-trifluoroethanone is a specialized trifluoroacetylated tetraazacyclotetradecane derivative, serving as a crucial synthetic intermediate and a versatile ligand precursor. Its value lies in its ability to introduce multiple trifluoroacetyl protecting groups and coordinate with metal ions, enabling advanced chemical synthesis and material development. This high-purity compound is essential for researchers and manufacturers in pharmaceutical development, advanced materials science, and catalysis, particularly for creating complex macrocyclic frameworks and fluorinated molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing complex macrocyclic drug candidates, particularly in oncology and diagnostic imaging agent development.
• Ligand Synthesis: Precursor for creating sophisticated chelating agents and ligands used in transition metal catalysis and coordination chemistry.
• Fluorine Chemistry Research: Valuable reagent for studying the effects of multiple trifluoroacetyl groups on molecular properties and reactivity.
• Material Science: Used in the development of novel fluorinated polymers and advanced organic frameworks with specific electronic or surface properties.
• Catalyst Development: Serves as a scaffold for constructing heterogeneous and homogeneous catalysts for specialized organic transformations.
• Analytical Chemistry: Potential use as a derivatization agent or a standard in chromatographic and spectroscopic method development.

Basic Information

Product Name	1-[4,8-bis-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-yl]-2,2,2-trifluoroethanone
CAS No.	406939-92-2
Molecular Formula	C18H22F9N4O3
Molecular Weight	522.38 g/mol
Synonyms	1,4,8-Tris(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane; 1,4,8-Tris(trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane; N,N',N''-Tris(trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane; 1,4,8,11-Tetraazacyclotetradecane-1,4,8-triyltris(2,2,2-trifluoroethanone); Tris(trifluoroacetyl)cyclam derivative; TFA-cyclam tris-derivative; 1,4,8-Tris-TFA-cyclam
EINECS	Contact for details

Quality Control

Our 1-[4,8-bis-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-yl]-2,2,2-trifluoroethanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP and ISO 9001 compliant production for applications requiring the highest standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to atmospheric moisture. Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.