Description

Proline, 4-Fluoro-1-Methyl-, Methyl Ester, L- (8Ci) is a fluorinated derivative of the amino acid proline, specifically modified as a methyl ester. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially protease inhibitors and other enzyme-targeted drugs.
• Peptidomimetics Research: Used to incorporate fluorinated proline analogs into peptide chains to study and enhance metabolic stability, bioavailability, and conformational properties.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and plant growth regulators with improved efficacy.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological mechanisms and protein-ligand interactions.
• Asymmetric Catalysis: Can be used as a precursor for chiral ligands or catalysts in stereoselective synthesis.
• Material Science: Potential monomer or modifier for creating specialized polymers with unique properties.

Basic Information

Item	Detail
Product Name	Proline, 4-Fluoro-1-Methyl-, Methyl Ester, L- (8Ci)
CAS No.	13135-68-7
Molecular Formula	C7H12FNO2
Molecular Weight	161.17 g/mol
Synonyms	L-4-Fluoro-1-methylproline methyl ester; Methyl L-4-fluoro-1-methylprolinate; (2S,4S)-4-Fluoro-1-methylpyrrolidine-2-carboxylic acid methyl ester; 4-Fluoro-1-methyl-L-proline methyl ester; Fluoroproline derivative; 13135-68-7; 4-Fluoro-1-methylproline methyl ester (L-)
EINECS	Contact for details

Quality Control

Our Proline, 4-Fluoro-1-Methyl-, Methyl Ester, L- (8Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and isomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.