Description

4,4,4-Trifluoro-2-Propyl-3-Oxobutyric Acid Ethyl Ester is a high-value fluorinated organic building block. This compound is critical for introducing the trifluoromethyl group into complex molecular architectures, a key modification for enhancing metabolic stability and lipophilicity in active ingredients. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel compounds and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Material Science Precursor: Serves as a starting material for synthesizing fluorinated polymers and specialty chemicals with unique surface properties and chemical resistance.
• Organic Synthesis Building Block: Employed in various name reactions, such as Claisen condensations and Michael additions, to construct complex, fluorinated ketones and esters.
• Ligand and Catalyst Development: Used in the preparation of novel fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4,4,4-Trifluoro-2-Propyl-3-Oxobutyric Acid Ethyl Ester
CAS No.	10556-91-9
Molecular Formula	C9H13F3O3
Molecular Weight	226.19 g/mol
Synonyms	Ethyl 4,4,4-Trifluoro-2-propyl-3-oxobutanoate; Ethyl 4,4,4-Trifluoro-3-oxo-2-propylbutyrate; 3-Oxobutyric Acid, 4,4,4-Trifluoro-2-propyl-, Ethyl Ester; 4,4,4-Trifluoro-2-propylacetoacetic acid ethyl ester; 2-Propyl-4,4,4-trifluoro-3-oxobutyric acid ethyl ester; Ethyl 2-propyl-4,4,4-trifluoroacetoacetate; TFPOBAE
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluoro-2-Propyl-3-Oxobutyric Acid Ethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.