Description

Betamethasone (Hydrochloride) CAS NO 956901-32-9 is a synthetic glucocorticoid corticosteroid, specifically the hydrochloride salt form of betamethasone, known for its potent anti-inflammatory and immunosuppressive properties. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of advanced pharmaceutical formulations. It is primarily required by manufacturers in the pharmaceutical and biotechnology sectors for the development and production of injectable and topical corticosteroid medications.

Application

• Pharmaceutical API: Core active ingredient in the manufacture of injectable corticosteroid solutions for treating severe inflammation, allergic reactions, and autoimmune disorders.
• Topical Formulations: Used in creams, ointments, and lotions for dermatological conditions such as eczema, psoriasis, and contact dermatitis.
• Ophthalmic Preparations: Key component in eye drops and ointments for treating inflammatory eye conditions.
• Veterinary Medicine: Employed in anti-inflammatory and anti-allergy treatments for animals.
• Research & Development: Serves as a critical reference standard and building block in biochemical research and new drug discovery programs.
• Compounding Pharmacy: Used by specialized pharmacies to prepare customized medication doses for specific patient needs.

Basic Information

Product Name	Betamethasone (Hydrochloride)
CAS No.	956901-32-9
Molecular Formula	C22H29ClO5 • HCl
Molecular Weight	461.38 g/mol
Synonyms	Betamethasone HCl; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione hydrochloride; Betamethasone 17,21-dihydrochloride; Betamethasone hydrochloride; 1-Dehydro-9α-fluoro-16β-methylhydrocortisone hydrochloride; NSC-39470; Flubenisolone hydrochloride
EINECS	Contact for details

Quality Control

Our Betamethasone (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide full traceability and support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopoeial standards (USP/EP). A detailed Certificate of Analysis (COA) is available for every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Specific Optical Rotation	+115° to +125° (c=1 in dioxane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.