Description

4-Nitro-2-(Trifluoromethoxy)Benzyl Bromide is a high-value, multi-functional organic building block characterized by its reactive benzyl bromide group and electron-withdrawing nitro and trifluoromethoxy substituents. This compound is essential for facilitating efficient carbon-carbon and carbon-heteroatom bond formation in complex synthetic pathways, offering chemists a versatile handle for molecular diversification. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing candidates for central nervous system (CNS) and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in catalytic systems and as a scaffold in material science research.
• Cross-Coupling Reactions: An effective electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Nucleophilic Substitution: The benzyl bromide moiety is highly reactive towards various nucleophiles (amines, thiols, alkoxides) for functional group interconversion.
• Fluorinated Compound Research: A valuable reagent for incorporating the trifluoromethoxy group into target molecules, a motif known to improve lipophilicity and bioavailability.

Basic Information

Product Name	4-Nitro-2-(Trifluoromethoxy)Benzyl Bromide
CAS No.	955946-10-8
Molecular Formula	C8H5BrF3NO3
Molecular Weight	300.03 g/mol
Synonyms	1-(Bromomethyl)-4-nitro-2-(trifluoromethoxy)benzene; 2-(Trifluoromethoxy)-4-nitrobenzyl bromide; α-Bromo-4-nitro-2-(trifluoromethoxy)toluene; (4-Nitro-2-(trifluoromethoxy)phenyl)methyl bromide; 4-Nitro-2-trifluoromethoxybenzyl bromide; Benzene, 1-(bromomethyl)-4-nitro-2-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 4-Nitro-2-(Trifluoromethoxy)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles via HPLC, NMR, and other relevant methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.