Description

4-(Difluoromethoxy)-3-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoromethoxy and fluorine substituents impart desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorinated motifs into novel molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where fluorination enhances bioactivity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed in the synthesis of electron-transport materials and semiconductors for OLEDs and other electronic devices.
• Fluorinated Polymer Research: Acts as a monomer or modifier in the development of specialty polymers with enhanced chemical resistance and thermal stability.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and constructing complex aromatic systems in academic and industrial labs.

Basic Information

Product Name	4-(Difluoromethoxy)-3-Fluorobenzonitrile
CAS No.	954388-59-1
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	3-Fluoro-4-(difluoromethoxy)benzonitrile; 4-(Difluoromethoxy)-3-fluorobenzonitrile; Benzonitrile, 3-fluoro-4-(difluoromethoxy)-; 3-Fluoro-4-difluoromethoxybenzonitrile; 954388-59-1; 4-Difluoromethoxy-3-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-3-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.