Description

3-(3,4-Difluorophenoxy)Azetidine is a high-value, nitrogen-containing heterocyclic building block featuring a difluorophenoxy substituent. This compound is critical for medicinal chemistry research and development, offering a versatile scaffold for creating novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of advanced drug candidates, particularly in therapeutic areas where fluorine substitution is advantageous.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug molecules, especially for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the azetidine and difluorophenoxy moieties contribute to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for designing novel ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	3-(3,4-Difluorophenoxy)Azetidine
CAS No.	954220-76-9
Molecular Formula	C9H9F2NO
Molecular Weight	185.17 g/mol
Synonyms	Azetidine, 3-(3,4-difluorophenoxy)-; 3-(3,4-Difluorophenoxy)azetidine; 954220-76-9; 3-(3,4-Difluorophenoxy)-1-azacyclobutane; 3-(3,4-Difluorophenoxy)azacyclobutane; 1-Azetidine, 3-(3,4-difluorophenoxy)-; 3-(3,4-Difluorophenoxy)azetidine (CAS 954220-76-9)
EINECS	Contact for details

Quality Control

Our 3-(3,4-Difluorophenoxy)Azetidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The product may be hygroscopic; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.