Description

Dihydrogentrifluoride Polymer-Supported is a specialized reagent where the reactive dihydrogentrifluoride (H2F3) species is immobilized on a solid polymer support. This innovative format provides a safer, more controllable, and convenient alternative to handling highly reactive and volatile fluoride species in solution. It is engineered for use in advanced organic synthesis, particularly in the pharmaceutical and agrochemical industries, where it facilitates key fluorination and deprotection reactions with enhanced operational safety and simplified work-up procedures.

Application

• Nucleophilic Fluorination: A key reagent for the selective introduction of fluorine atoms into complex organic molecules in pharmaceutical R&D.
• Silicon Protecting Group Removal: Efficient cleavage of tert-butyldimethylsilyl (TBDMS) and related silyl ethers in multi-step synthesis.
• Solid-Phase Synthesis: Enables fluorination and deprotection steps in combinatorial chemistry and peptide synthesis on solid support.
• Agrochemical Intermediate Synthesis: Used in the preparation of fluorinated active ingredients for crop protection products.
• Material Science Research: Surface modification and fluorination of polymers and other advanced materials.
• Process Chemistry: Offers advantages in flow chemistry and continuous manufacturing due to its heterogeneous, supported nature.

Basic Information

Product Name	Dihydrogentrifluoride Polymer-Supported
CAS No.	12260-12-7
Molecular Formula	H2F3 (active species)
Molecular Weight	59.01 g/mol (active species)
Synonyms	Polymer-Bound Dihydrogentrifluoride; H2F3 on Polymer Support; Trihydrogen Difluoride Polymer-Supported; Hydrogen Trifluoride Polymer-Supported; Solid-Supported HF-Pyridine Complex; Immobilized Fluorinating Agent; TAS-F Polymer Analog; Fluoride Source on Solid Support
EINECS	Contact for details

Quality Control

Every batch of our Dihydrogentrifluoride Polymer-Supported reagent is manufactured under strict quality management protocols. We ensure consistent fluoride loading capacity, particle size distribution, and chemical stability. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing assay, moisture content, and performance in model reactions are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. Due to its fluoride/strong alkali nature and high volatility of the active species, the container must be kept tightly sealed to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to beige polymeric beads
Identification (IR)	Conforms to reference spectrum
Fluoride Loading	1.0 - 3.0 mmol/g (typical)
Assay (Titration)	≥ 90% of stated loading
Moisture Content (KF)	≤ 2.0 % w/w
Particle Size (Mesh)	100 - 200 mesh
Solvent Retention	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.