Description

13-Deoxyepirubicin is a synthetic derivative of the anthracycline class of compounds, closely related to the chemotherapeutic agent epirubicin. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a key intermediate or active pharmaceutical ingredient (API) in oncology drug discovery. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in the synthesis and evaluation of novel anti-cancer therapeutics. The product, identified as CAS NO 952648-77-0, is supplied to meet the stringent requirements of advanced medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel anthracycline-based chemotherapeutic agents.
• Oncology Research: Used as a reference standard or experimental compound in biochemical and cellular assays to study mechanisms of action, cytotoxicity, and drug resistance.
• API Development: Employed in the research and process development stages for creating new Active Pharmaceutical Ingredients targeting various cancers.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs aiming to modify the epirubicin scaffold to improve efficacy or reduce side effects.
• Preclinical Studies: Utilized in in vitro and in vivo models to evaluate pharmacokinetics, pharmacodynamics, and preliminary safety profiles.

Basic Information

Product Name	13-Deoxyepirubicin
CAS No.	952648-77-0
Molecular Formula	C27H29NO10
Molecular Weight	527.52 g/mol
Synonyms	(8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione; 13-Deoxy-4'-epidoxorubicin; 4'-Epi-13-deoxydoxorubicin
EINECS	Contact for details

Quality Control

Our 13-Deoxyepirubicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Red to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.