Description

5-Amino-2,4-Difluorobenzonitrile is a high-purity, multi-functional aromatic nitrile building block. This compound is valued for its unique combination of an amino group and fluorine substituents, which are critical for modulating the physicochemical properties of advanced molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides, where the difluoro and nitrile groups contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for advanced polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Employed in the production of specialized dyes and pigments, leveraging the amino group for chromophore development.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.

Basic Information

Product Name	5-Amino-2,4-Difluorobenzonitrile
CAS No.	952285-54-0
Molecular Formula	C7H4F2N2
Molecular Weight	154.12 g/mol
Synonyms	2,4-Difluoro-5-aminobenzonitrile; 5-Amino-2,4-difluorobenzene carbonitrile; Benzonitrile, 5-amino-2,4-difluoro-; 952285-54-0; 5-Amino-2,4-difluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 5-Amino-2,4-Difluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request, supporting your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening the primary container.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.