Description

1-Bromo-5-Chloro-4-Fluoro-2-Methoxybenzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its precise substitution pattern makes it a valuable scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical industries. This compound is primarily sought after by R&D chemists and process development scientists for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine and chlorine atoms for enhanced bioactivity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, enabling rapid diversification of chemical space.

Basic Information

Product Name	1-Bromo-5-Chloro-4-Fluoro-2-Methoxybenzene
CAS No.	949892-08-4
Molecular Formula	C7H5BrClFO
Molecular Weight	239.47 g/mol
Synonyms	2-Bromo-4-Chloro-5-Fluoroanisole; 4-Bromo-2-Chloro-5-Fluoroanisole; 5-Chloro-4-Fluoro-2-Methoxy-1-Bromobenzene; 1-Bromo-5-Chloro-4-Fluoro-2-Methoxybenzene; Benzene, 1-bromo-5-chloro-4-fluoro-2-methoxy-; 2-Methoxy-4-bromo-5-chlorofluorobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Chloro-4-Fluoro-2-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging are performed under controlled lighting conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.