Description

(E)-Olopatadine Hydrochloride CAS NO 949141-22-4 is the specific geometric isomer of a potent, selective histamine H1-receptor antagonist. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of advanced ophthalmic and pharmaceutical formulations. It is primarily required by pharmaceutical manufacturers and research institutions developing next-generation anti-allergic and anti-inflammatory therapeutics.

Application

• Primary Active Pharmaceutical Ingredient (API) in ophthalmic solutions for treating allergic conjunctivitis.
• Key Intermediate in the synthesis of novel antihistamine drugs and related pharmaceutical compounds.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Research Chemical for pharmacological studies targeting histamine pathways and inflammatory responses.
• Formulation Development for nasal sprays, topical creams, and other dosage forms requiring potent H1-antagonism.

Basic Information

Product Name	(E)-Olopatadine Hydrochloride
CAS No.	949141-22-4
Molecular Formula	C21H23NO3·HCl
Molecular Weight	373.88 g/mol (as hydrochloride salt)
Synonyms	(E)-Olopatadine HCl; (11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride; (E)-Isomer of Olopatadine Hydrochloride; KW-4679 (E)-form; Allelock (Isomer); Patanol/Pataday API Isomer; Z-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (E)-Olopatadine Hydrochloride is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical development. Each batch is tested to ensure identity, potency, and the absence of critical impurities, including the (Z)-isomer. A comprehensive Certificate of Analysis (COA) documenting compliance with in-house specifications is provided. We support development with GMP-grade material and can align with relevant pharmacopeial standards (USP/EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5% (on anhydrous basis)
Isomeric Purity (E-Isomer)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.