Description

4-Morpholinecarboxamide, n-(2-Aminoethyl)-, Ethanedioate (Landiolol) is the ethanedioate (oxalate) salt form of the highly selective, ultra-short-acting β-1 adrenergic receptor antagonist, Landiolol. This compound is of critical importance as a key pharmaceutical intermediate or reference standard in the development and production of fast-acting cardioselective β-blocker medications. It is primarily needed by pharmaceutical R&D laboratories, active pharmaceutical ingredient (API) manufacturers, and analytical service providers focused on cardiovascular therapeutics. The precise synthesis and high purity of this salt form are essential for ensuring the efficacy and safety profile of the final drug product.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of the ultra-short-acting β-blocker, Landiolol hydrochloride.
• Reference Standard: Used in analytical chemistry for method development, validation, and quality control testing of Landiolol-based drug substances and products.
• Research & Development: Employed in preclinical and clinical research to study the pharmacokinetics, metabolism, and structure-activity relationships of cardioselective β-blockers.
• Active Pharmaceutical Ingredient (API) Manufacturing: A key starting material or intermediate in GMP-compliant production processes for cardiovascular drugs.
• Impurity Profiling: Utilized as a marker to identify and quantify related substances during stability studies and regulatory submissions.

Basic Information

Product Name	4-Morpholinecarboxamide, n-(2-Aminoethyl)-, Ethanedioate (Landiolol)
CAS No.	947674-94-4
Molecular Formula	C20H34N4O7
Molecular Weight	442.51 g/mol
Synonyms	Landiolol Oxalate; ONO-1101 Oxalate; N-[2-[4-[(2-Hydroxy-3-phenoxypropyl)amino]butoxy]ethyl]morpholine-4-carboxamide Oxalate; 4-Morpholinecarboxamide, N-[2-[4-[(2-hydroxy-3-phenoxypropyl)amino]butoxy]ethyl]-, ethanedioate (1:1); (RS)-N-[2-[4-[(2-Hydroxy-3-phenoxypropyl)amino]butoxy]ethyl]morpholine-4-carboxamide Oxalate
EINECS	Contact for details

Quality Control

Our 4-Morpholinecarboxamide, n-(2-Aminoethyl)-, Ethanedioate (Landiolol) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for assay and impurity profiling, to ensure it meets stringent specifications suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.