Description

Propranolol Hydrochloride CAS NO 318-98-9 is a potent, non-selective β-adrenergic receptor blocking agent. This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacturing of cardiovascular and other therapeutic medications. It is primarily required by pharmaceutical manufacturers, research institutions, and compounding pharmacies for the production of tablets, capsules, and injectable formulations.

Application

• Pharmaceutical API: Core active ingredient in antihypertensive and anti-anginal medications.
• Cardiovascular Drugs: Manufacture of tablets and capsules for treating high blood pressure, angina pectoris, and cardiac arrhythmias.
• Migraine Prophylaxis: Used in the formulation of preventative treatments for migraine headaches.
• Anxiety Management: Component in medications for situational anxiety and performance anxiety.
• Thyrotoxicosis Adjunct Therapy: Employed in managing symptoms of hyperthyroidism.
• Pharmaceutical R&D: Reference standard and raw material for drug discovery, pharmacokinetic studies, and new formulation development.
• Compounding Pharmacy: Raw material for customized medication preparations to meet specific patient needs.

Basic Information

Product Name	Propranolol Hydrochloride
CAS No.	318-98-9
Molecular Formula	C16H21NO2 • HCl
Molecular Weight	295.80 g/mol
Synonyms	1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol Hydrochloride; Propranolol HCl; ICI 45520; Avlocardyl; Inderal; Angilol; Bedranol; β-Tim; Dociton; Efektolol;
EINECS	206-268-1

Quality Control

Our Propranolol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets or exceeds relevant pharmacopoeial standards, including USP, EP, and BP monographs. Key parameters such as identity, purity, and impurity profiles are verified. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Specific Rotation	-1.0° to +1.0° (c=5 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.