Description

R-(+)-Bisoprolol is the pharmacologically active enantiomer of the β-1 selective adrenergic receptor blocker, bisoprolol. This high-purity chiral intermediate is critical for the synthesis of enantiomerically pure cardiovascular pharmaceuticals. It is primarily required by advanced pharmaceutical manufacturers and research institutions developing next-generation cardioselective β-blockers with optimized efficacy and reduced side-effect profiles.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Key chiral building block for the production of enantiopure bisoprolol fumarate and other related β-blocker APIs.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to investigate the specific pharmacokinetics and pharmacodynamics of the (R)-enantiomer.
• Process Chemistry & Optimization: Serves as a reference standard and starting material for developing and scaling up asymmetric synthesis routes.
• Analytical Standard: Employed as a high-purity certified reference material (CRM) for HPLC, LC-MS, and chiral assay method development and validation.
• Formulation Development: Used in the development of novel drug delivery systems for cardiovascular medications.

Basic Information

Product Name	R-(+)-Bisoprolol
CAS No.	111051-40-2
Molecular Formula	C18H31NO4
Molecular Weight	325.45 g/mol
Synonyms	(R)-(+)-Bisoprolol; (R)-Bisoprolol; (+)-Bisoprolol; (2R)-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol; 1-(Isopropylamino)-3-[p-(2-isopropoxyethoxymethyl)phenoxy]-2-propanol (R)-form; Dexbisoprolol; R-Bisoprolol Base
EINECS	Contact for details

Quality Control

Our R-(+)-Bisoprolol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D and API synthesis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.