Description

(-)-Nebivolol CAS NO 118457-16-2 is a highly selective β-1 adrenergic receptor antagonist, representing the pharmacologically active enantiomer of the racemic drug nebivolol. This compound is of critical importance for the development and production of enantiomerically pure cardiovascular pharmaceuticals. It is primarily required by pharmaceutical manufacturers and research institutions focused on creating advanced treatments for hypertension and heart failure, where its unique mechanism of action offers significant therapeutic benefits.

Application

• Active Pharmaceutical Ingredient (API) in antihypertensive and cardioprotective medications.
• Reference Standard for analytical method development and quality control in pharmaceutical laboratories.
• Research Chemical for pharmacological studies investigating β-blocker mechanisms and cardiovascular disease.
• Process Development for the synthesis and scale-up of enantiomerically pure nebivolol.
• Formulation Studies for developing novel drug delivery systems for cardiovascular therapies.

Basic Information

Product Name	(-)-Nebivolol
CAS No.	118457-16-2
Molecular Formula	C22H25F2NO4
Molecular Weight	405.44 g/mol
Synonyms	(-)-Nebivolol; (S,R,R,R)-Nebivolol; D-Nebivolol; Nebivolol Enantiomer; Bystolic (Active Enantiomer); 1-(6-Fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]amino]ethanol (S,R,R,R)-isomer; UNII-4S79A89O9C
EINECS	Contact for details

Quality Control

Our (-)-Nebivolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure compliance with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.