Description

(+/-)-4-Hydroxypropranolol, Hydrochloride is a key metabolite and chemical reference standard of the widely used β-blocker, propranolol. This compound is essential for analytical and pharmacological research, providing a critical benchmark for studying drug metabolism, pharmacokinetics, and developing accurate bioanalytical methods. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on cardiovascular drug development and forensic toxicology.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative and qualitative analysis of propranolol and its metabolites in drug formulations and biological matrices.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of propranolol.
• Bioanalytical Method Development: Used to develop, validate, and calibrate analytical methods such as HPLC, LC-MS/MS, and GC-MS for drug monitoring and forensic analysis.
• Pharmacological Studies: Employed in research to understand the activity and potential effects of propranolol metabolites on β-adrenergic receptors.
• Impurity Profiling: Acts as a known impurity standard in the quality control of propranolol active pharmaceutical ingredient (API) manufacturing to ensure product purity and compliance.
• Toxicology and Forensic Science: Used as a calibrant in forensic labs for the accurate detection and quantification of propranolol and its metabolites in toxicological screenings.

Basic Information

Item	Detail
Product Name	(+/-)-4-Hydroxypropranolol, Hydrochloride
CAS No.	10476-53-6
Molecular Formula	C₁₆H₂₂ClNO₃
Molecular Weight	311.80 g/mol
Synonyms	4-Hydroxypropranolol HCl; 1-(Isopropylamino)-3-(4-hydroxy-1-naphthyloxy)-2-propanol Hydrochloride; (±)-4-Hydroxypropranolol Hydrochloride; Propranolol Metabolite II Hydrochloride; 4'-Hydroxypropranolol Hydrochloride; 1-(Isopropylamino)-3-(4-hydroxynaphthalen-1-yloxy)propan-2-ol Hydrochloride; DL-4-Hydroxypropranolol Hydrochloride
EINECS	Contact for details

Quality Control

Our (+/-)-4-Hydroxypropranolol, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including identification, purity assay, and impurity profiling via advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided to ensure traceability and compliance with your research or quality control requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.