Description

Esmolol is a highly selective, ultra-short-acting β-1 adrenergic receptor blocking agent. This compound is critically important for its rapid onset and short duration of action, making it a valuable tool for precise cardiovascular control. It is primarily required by pharmaceutical manufacturers and research institutions developing or producing injectable formulations for the acute management of tachycardia and hypertension, particularly in perioperative and emergency settings.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of injectable antiarrhythmic and antihypertensive medications.
• Hospital/Clinical Formulations: Used in ready-to-use or compounded solutions for the rapid control of atrial fibrillation, atrial flutter, and sinus tachycardia.
• Perioperative Care: Critical for managing hemodynamic stability and preventing myocardial ischemia during and after surgical procedures.
• Emergency Medicine: Employed in urgent care settings for the short-term treatment of severe hypertension and tachyarrhythmias.
• Cardiovascular Research: Serves as a key reference standard and investigational compound in pharmacological studies of β-blockade.
• Drug Delivery System Development: Used in research focused on novel parenteral delivery mechanisms for ultra-short-acting drugs.

Basic Information

Product Name	Esmolol
CAS No.	103598-03-4
Molecular Formula	C16H25NO4
Molecular Weight	295.38 g/mol
Synonyms	Esmolol Hydrochloride; ASL-8052; Brevibloc; Methyl 3-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}propionate; (±)-Methyl p-[2-hydroxy-3-(isopropylamino)propoxy]hydrocinnamate
EINECS	Contact for details

Quality Control

Our Esmolol is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing parameters such as assay, related substances, residual solvents, and identification. We support compliance with ICH guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.