Description

(-)-Hydroxypropranolol Hydrochloride CAS NO 135201-50-2 is a high-purity, enantiomerically pure chemical compound primarily used as a key intermediate and reference standard in pharmaceutical research and development. This compound is critical for studies involving β-adrenergic receptor pharmacology, enabling precise investigation of stereospecific drug interactions and metabolic pathways. It is essential for pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on cardiovascular research, drug metabolism studies, and the synthesis of specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced β-blocker drugs and their metabolites.
• Pharmacological Research: Used as a reference standard in studies of β-adrenergic receptor binding, selectivity, and antagonism.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as a metabolite standard for propranolol in ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Analytical Chemistry: Employed as a certified reference material (CRM) for HPLC, LC-MS, and GC-MS method development and validation.
• Academic Research: Utilized in university and institutional labs for cardiovascular and neuropharmacology research projects.
• Impurity Standard: Acts as a specified impurity standard for quality control in the manufacturing of propranolol hydrochloride and related pharmaceuticals.

Basic Information

Product Name	(-)-Hydroxypropranolol Hydrochloride
CAS No.	135201-50-2
Molecular Formula	C₁₆H₂₂ClNO₃
Molecular Weight	311.80 g/mol
Synonyms	1-[(1S)-1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-4-[(2S)-oxiran-2-ylmethoxy]benzene Hydrochloride; (S)-(-)-4-[2-Hydroxy-3-(isopropylamino)propoxy]benzeneethanol, α-Oxiranylmethyl-, Hydrochloride; (-)-4-[2-Hydroxy-3-(isopropylamino)propoxy]benzeneethanol α-(Oxiranylmethyl) Hydrochloride; L-Hydroxypropranolol HCl; (S)-Hydroxypropranolol Hydrochloride; Propranolol Metabolite Standard; 1'‑Hydroxypropranolol Hydrochloride
EINECS	Contact for details

Quality Control

Our (-)-Hydroxypropranolol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical parameters. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.