Description

Metoprolol Succinate CAS NO 151705-75-8 is the succinate salt form of metoprolol, a widely used cardioselective β-1 adrenergic receptor blocker. This high-purity active pharmaceutical ingredient (API) is critical for the formulation of extended-release solid dosage forms, ensuring consistent therapeutic delivery. It is primarily required by pharmaceutical manufacturers and research institutions developing cardiovascular medications for hypertension, angina, and heart failure management.

Application

• Pharmaceutical API: Core active ingredient in extended-release tablet formulations for controlled drug delivery.
• Hypertension Treatment: Manufacture of medications used to manage high blood pressure (antihypertensives).
• Angina Pectoris Therapy: Production of drugs for preventing chest pain caused by reduced blood flow to the heart.
• Heart Failure Management: Used in formulations for certain types of chronic heart failure to improve survival and reduce hospitalizations.
• Clinical Research: Reference standard and raw material for pharmacokinetic and pharmacodynamic studies.
• Generic Drug Manufacturing: Sourcing of API for cost-effective generic versions of branded metoprolol succinate medications.
• Formulation Development: Excipient compatibility and stability studies for new drug delivery systems.

Basic Information

Product Name	Metoprolol Succinate
CAS No.	151705-75-8
Molecular Formula	C34H56N2O8
Molecular Weight	620.82 g/mol
Synonyms	Metoprolol Succinate Salt; Metoprolol Hydrogen Succinate; (±)-Metoprolol Succinate; 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol Succinate; Toprol-XL (Brand Name API); Lopressor Succinate; Seloken ZOC; Betaloc ZOK; Succinic acid compound with metoprolol (1:1)
EINECS	Contact for details

Quality Control

Our Metoprolol Succinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided, detailing compliance with relevant pharmacopeial standards such as USP, EP, and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.15% Total impurities: ≤ 0.5%
Heavy Metals	≤ 20 ppm
Microbial Limits	Meets EP/USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.