Description

Nebivolol Hydrochloride CAS NO 152520-56-4 is a highly selective β-1 adrenergic receptor blocker, chemically known as (αR,α'R,2R,2'S)-rel-α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride. This active pharmaceutical ingredient (API) is critical for the formulation of modern cardiovascular therapeutics, offering a favorable hemodynamic profile. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of antihypertensive and heart failure medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of hypertension.
• Cardiovascular Drug Formulation: Formulation of tablets and other oral solid dosages targeting selective β-1 blockade.
• Clinical Research Material: Serves as a reference standard and raw material in pharmacokinetic, pharmacodynamic, and clinical trial studies.
• Generic Drug Manufacturing: Essential for companies producing bioequivalent generic versions of nebivolol-based medications.
• Combination Therapy Development: Used in research for fixed-dose combination drugs with other antihypertensive agents.
• Analytical Standard: Acts as a high-purity standard for quality control and analytical method development in QC laboratories.

Basic Information

Product Name	Nebivolol Hydrochloride
CAS No.	152520-56-4
Molecular Formula	C22H25F2NO4 • HCl
Molecular Weight	441.90 g/mol (Free base: 405.44)
Synonyms	Nebivolol HCl; (αR,α'R,2R,2'S)-rel-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] Hydrochloride; BRL-35135; R-65824; R 65824; LOBIVON; NEBILET; 1,1'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] Hydrochloride (racemic mixture reference)
EINECS	Contact for details

Quality Control

Our Nebivolol Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications. Comprehensive testing includes identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.5% - 101.5% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.