Description

Butyryl Timolol is a key pharmaceutical intermediate and a derivative of the β-blocker Timolol. This compound is of significant value in the research and development of novel ophthalmic and cardiovascular drug formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the synthesis of advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of Timolol and its related analogs for therapeutic use.
• Ophthalmic Drug Research: Used in the development of new glaucoma medications, leveraging its β-adrenergic blocking properties.
• Cardiovascular Drug Development: Serves as a precursor in research for drugs targeting hypertension and arrhythmias.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway studies of Timolol.
• Chemical Reference Standard: Acts as a high-purity standard for analytical testing and quality control in pharmaceutical labs.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for β-blocker production.

Basic Information

Product Name	Butyryl Timolol
CAS No.	106351-79-5
Molecular Formula	C17H26N4O3S
Molecular Weight	366.48 g/mol
Synonyms	Timolol Butyrate; (S)-1-(tert-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-butanol Butyrate; Butyric acid, ester with (S)-timolol; 4-Morpholinecarbothioic acid, 3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl ester; Timolol 3-Butyrate
EINECS	Contact for details

Quality Control

Our Butyryl Timolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.