Description

1-Propanone, 1-(4-(2-Hydroxy-3-(Propylamino)Propoxy)-3-(Propoxymethyl) Phenyl)-, (E)-2-Butenedioate (2:1) (Salt) is a high-purity, non-racemic salt form of a key pharmaceutical intermediate. This compound is critical for ensuring the precise stereochemistry and bioavailability required in advanced active pharmaceutical ingredient (API) synthesis. It is primarily utilized by research institutions and pharmaceutical manufacturers developing targeted cardiovascular and neurological therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of advanced β-adrenergic blocking agents (β-blockers).
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the research and scale-up production of novel drug candidates targeting hypertension and angina.
• Asymmetric Synthesis: Used in stereoselective chemical reactions to produce enantiomerically pure compounds for pharmacological evaluation.
• Process Chemistry & Optimization: Employed in route scouting and process development for more efficient and sustainable API manufacturing.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical development.

Basic Information

Product Name	1-Propanone, 1-(4-(2-Hydroxy-3-(Propylamino)Propoxy)-3-(Propoxymethyl) Phenyl)-, (E)-2-Butenedioate (2:1) (Salt)
CAS No.	152271-02-8
Molecular Formula	C20H31NO5 · ½ C4H4O4
Molecular Weight	~402.5 g/mol (for salt form)
Synonyms	(S)-1-(4-(2-Hydroxy-3-(Propylamino)Propoxy)-3-(Propoxymethyl)Phenyl)-1-Propanone Fumarate (2:1) Salt; (S)-1-Propanone, 1-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-3-(propoxymethyl)phenyl]-, (2E)-2-butenedioate (2:1); Nebivolol Related Compound Fumarate Salt; Nebivolol Impurity Fumarate; 1-[4-[2-Hydroxy-3-(Propylamino)Propoxy]-3-(Propoxymethyl)Phenyl]-1-Propanone Fumarate; (S)-1-(4-(3-Isopropylamino-2-hydroxypropoxy)-3-(propoxymethyl)phenyl)propan-1-one hemifumarate
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, to ensure compliance with ICH guidelines and customer-specific requirements. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.