Description

(+)-Nebivolol CAS NO 118457-15-1 is the pharmacologically active enantiomer of the β-blocker nebivolol. This high-purity chiral intermediate is critical for the synthesis of advanced cardiovascular pharmaceuticals, where stereochemical purity directly impacts therapeutic efficacy and safety. It is an essential building block for pharmaceutical manufacturers and research institutions developing next-generation treatments for hypertension and heart failure.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a key chiral intermediate in the industrial-scale production of the β-blocker Nebivolol hydrochloride.
• Pharmaceutical Research & Development: Serves as a critical reference standard and starting material in preclinical and clinical studies for cardiovascular drug candidates.
• Process Chemistry & Optimization: Used in the development and scaling of stereoselective synthesis routes within fine chemical and generic drug manufacturing.
• Analytical Method Development: Employed as a high-purity standard for HPLC, LC-MS, and chiral assay validation in quality control laboratories.
• Regulatory Filings: Provides the necessary enantiopure material for stability studies and impurity profiling required for regulatory submissions (e.g., FDA, EMA).

Basic Information

Product Name	(+)-Nebivolol
CAS No.	118457-15-1
Molecular Formula	C22H25F2NO4
Molecular Weight	405.44 g/mol
Synonyms	(+)-Nebivolol; (αR)-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]; d-Nebivolol; Dextro-Nebivolol; (R,R)-Nebivolol; UNII-8V32U4FZHJ; BRL-37344 (enantiomer); L 652,469 (enantiomer)
EINECS	Contact for details

Quality Control

Our (+)-Nebivolol is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical R&D and API synthesis. Comprehensive testing includes chiral purity assay, identification, and control of specified impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.