Description

Metoprolol Fumarate (200 Mg) is a high-purity, non-hygroscopic salt form of the widely used β-1 selective adrenergic receptor blocker, metoprolol. This specific formulation is critical for ensuring precise dosage, stability, and bioavailability in finished pharmaceutical products. It is an essential active pharmaceutical ingredient (API) and intermediate for manufacturers developing cardiovascular medications, primarily for the management of hypertension, angina, and heart failure.

Application

• Pharmaceutical API: Primary use as the active ingredient in solid oral dosage forms such as extended-release and immediate-release tablets (200 mg strength).
• Cardiovascular Therapeutics: Formulation of medications for treating high blood pressure (hypertension), chronic angina pectoris, and stable heart failure.
• Drug Product Development: Serves as a key intermediate in R&D for novel drug delivery systems and combination therapies.
• Reference Standard: Used in analytical laboratories for quality control, method development, and calibration in HPLC and other chromatographic assays.
• Generic Drug Manufacturing: A vital component for producers of bioequivalent generic versions of branded metoprolol medications.
• Clinical Trial Material: Supplied for use in Phase I-III clinical studies investigating cardiovascular treatments.

Basic Information

Product Name	Metoprolol Fumarate (200 Mg)
CAS No.	119637-66-0
Molecular Formula	C34H50N2O12
Molecular Weight	678.77 g/mol
Synonyms	Metoprolol Fumarate; Metoprolol hydrogen fumarate; (±)-Metoprolol fumarate salt; 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol fumarate; Lopressor Succinate (obsolete); Toprol-XL (specific to extended-release formulation); CGP 2175; H 93/26
EINECS	Contact for details

Quality Control

Our Metoprolol Fumarate is manufactured under strict quality management systems. Each batch is tested to ensure compliance with relevant pharmacopeial standards such as USP and EP. A comprehensive Certificate of Analysis (COA) is provided, detailing results for identity, purity, assay, and specified impurities. We are committed to supply chain reliability and consistent quality to support your regulatory filings and production schedules.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.