Description

2-Fluoro-3-Nitrobenzyl Bromide is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both an electrophilic benzyl bromide group and a nitro substituent, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used to introduce the 2-fluoro-3-nitrobenzyl moiety into novel herbicides, fungicides, and pesticides, leveraging fluorine's ability to enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for the preparation of specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of advanced organic materials, such as liquid crystals and organic semiconductors, where fluorinated aromatic units are desirable.
• Chemical Biology Probes: Useful for the synthesis of activity-based probes and fluorogenic substrates for enzyme studies and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A high-value intermediate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	2-Fluoro-3-Nitrobenzyl Bromide
CAS No.	946125-65-1
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.02 g/mol
Synonyms	1-(Bromomethyl)-2-fluoro-3-nitrobenzene; (2-Fluoro-3-nitrophenyl)methyl Bromide; α-Bromo-2-fluoro-3-nitrotoluene; 2-Fluoro-3-nitrobenzylbromide; 2-Fluoro-3-nitro-α-bromotoluene; 3-Nitro-2-fluorobenzyl Bromide; Benzene, 1-(bromomethyl)-2-fluoro-3-nitro-
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-Nitrobenzyl Bromide is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), identity confirmation, and impurity profile is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.