Description

Landiolol is a highly selective, ultra-short-acting β-1 adrenergic receptor antagonist. This compound is of significant interest for its rapid onset and offset of action, making it a valuable agent in clinical settings requiring precise hemodynamic control. It is primarily utilized in the pharmaceutical industry for the development of injectable formulations used in perioperative and critical care medicine to manage tachycardia and myocardial ischemia.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of injectable solutions for the acute control of heart rate during surgery.
• Cardiac Stress Testing: Used as a pharmacological agent to safely induce controlled tachycardia for diagnostic imaging procedures.
• Research & Development: A critical reference standard and intermediate in pharmacological studies targeting β-1 adrenergic receptors.
• Critical Care Medicine: Formulated for use in intensive care units (ICUs) to manage supraventricular tachyarrhythmias in patients where rapid titration is necessary.
• Drug Delivery System Development: Investigated in advanced formulation research for targeted or sustained-release delivery systems.

Basic Information

Product Name	Landiolol
CAS No.	944919-03-3
Molecular Formula	C25H36N2O4
Molecular Weight	428.57 g/mol
Synonyms	Landiolol Hydrochloride; ONO-1101; (2S)-2-{4-[(2S)-2-Hydroxy-3-{[2-(4-morpholinyl)ethyl]amino}propoxy]phenyl}acetamide; 4-[2-Hydroxy-3-(4-morpholinyl)propoxy]benzenepropanamide; Ultra-short-acting β1-blocker
EINECS	Contact for details

Quality Control

Our Landiolol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.