Description

Leuprolide Mesylate CAS NO 944347-41-5 is the mesylate salt form of leuprolide, a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH). This compound is a critical active pharmaceutical ingredient (API) valued for its potent and sustained action on the pituitary gland. It is primarily required by the pharmaceutical industry for the formulation of advanced hormonal therapies targeting conditions such as prostate cancer, endometriosis, and central precocious puberty.

Application

• Pharmaceutical API: Primary use as the active ingredient in long-acting injectable depot formulations for hormone-dependent therapies.
• Oncology Treatments: Manufacture of therapeutics for advanced prostate cancer and breast cancer, where hormone suppression is required.
• Gynecological Medicines: Key component in treatments for endometriosis and uterine fibroids (leiomyomata).
• Pediatric Endocrinology: Used in medications for the treatment of central precocious puberty (CPP).
• Veterinary Pharmaceuticals: Applied in fertility control and treatment of hormone-related disorders in animals.
• Research & Development: Serves as a reference standard and building block in peptide research and new drug discovery.

Basic Information

Product Name	Leuprolide Mesylate
CAS No.	944347-41-5
Molecular Formula	C₆₀H₈₈N₁₆O₁₄ • CH₄O₃S
Molecular Weight	1309.5 g/mol (approx.)
Synonyms	Leuprorelin Mesylate; Leuprolide Methanesulfonate; 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide Methanesulfonate; TAP-144 Mesylate; Abbott-43818 Mesylate; GnRH Agonist (Mesylate Salt); Leuprolide Acetate Analog (Mesylate); Leuprorelin Acetate (Mesylate Salt Alternative)
EINECS	Contact for details

Quality Control

Our Leuprolide Mesylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Specifications typically align with pharmacopeial expectations for peptide APIs. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 10 EU/mg
Specific Rotation	-30° to -40° (c=1 in H₂O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.