Description

Cetrorelix Acetate is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) that acts as a potent and competitive antagonist. This compound is of critical importance in controlled ovarian stimulation protocols, where it is used to prevent premature luteinizing hormone (LH) surges. It is primarily required by pharmaceutical manufacturers, clinical research organizations, and fertility clinics for the production of therapeutic agents and in advanced reproductive medicine.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in injectable formulations for fertility treatment.
• Assisted Reproductive Technology (ART): Key component in in vitro fertilization (IVF) cycles to control ovulation timing.
• Clinical Research: Used in preclinical and clinical studies investigating hormonal regulation and GnRH antagonist mechanisms.
• Drug Development: Serves as a reference standard and building block in the development of new peptide-based therapeutics.
• Veterinary Medicine: Potential applications in animal breeding and the management of reproductive disorders in livestock.

Basic Information

Product Name	Cetrorelix Acetate
CAS No.	120287-85-6
Molecular Formula	C70H92ClN17O14 • xC2H4O2
Molecular Weight	1431.0 g/mol (free base)
Synonyms	Cetrotide (Brand Name); Cetrorelix; Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2 Acetate; (Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(carbamoyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide acetate); GnRH Antagonist; Gonadotropin-Releasing Hormone Antagonist
EINECS	Contact for details

Quality Control

Our Cetrorelix Acetate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications suitable for pharmaceutical development. Certificates of Analysis (COA) detailing purity, related substances, residual solvents, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 8.0%
Acetic Acid Content	5.0% - 12.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 5.0 EU/mg
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.