Description

Teverelix is a synthetic decapeptide antagonist of the gonadotropin-releasing hormone (GnRH) receptor. This compound is a critical active pharmaceutical ingredient (API) used to achieve rapid and reversible suppression of gonadotropin and sex hormone secretion. It is primarily utilized in advanced pharmaceutical research and development, as well as in clinical applications within endocrinology and oncology. The product is supplied as Teverelix CAS NO 144743-92-0, meeting the stringent purity requirements for such applications.

Application

• Pharmaceutical API: Core active ingredient in injectable formulations for the treatment of hormone-dependent conditions.
• Endocrine Research: Used in preclinical and clinical studies to investigate GnRH receptor function and hormone regulation pathways.
• Oncology Therapeutics: Employed in therapies for prostate cancer and other malignancies influenced by sex hormones.
• Fertility Control: Key component in protocols for controlled ovarian stimulation and assisted reproductive technologies.
• Veterinary Medicine: Applied in animal health for reproductive management and the treatment of hormone-related disorders.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in laboratories.

Basic Information

Product Name	Teverelix
CAS No.	144743-92-0
Molecular Formula	C₈₁H₁₁₂ClN₂₁O₂₂
Molecular Weight	1811.3 g/mol
Synonyms	Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Hci-Leu-Lys(iPr)-Pro-D-Ala-NH₂; Teverelix acetate; Antarelix; EP-24332; GnRH Antagonist (Teverelix); Ac-3-(2-Naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-N6-(1-methylethyl)-D-lysyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-D-alaninamide
EINECS	Contact for details

Quality Control

Our Teverelix is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, mass spectrometry for identity confirmation, and tests for residual solvents and related substances. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0% (Total related substances ≤ 3.0%)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Acetate Content (IC)	2.0 - 8.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.