Description

(D-Ser4)-Histrelin is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH) with a specific D-amino acid substitution. This modification confers enhanced metabolic stability and a distinct pharmacological profile compared to its L-amino acid counterpart, making it a valuable tool for advanced research and development. It is primarily utilized by pharmaceutical researchers and manufacturers in the development of therapeutic agents targeting hormone-dependent conditions and in specialized biochemical studies.

Application

• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the development of novel GnRH-based therapeutics for oncology and endocrinology.
• Biochemical Research: Used as a probe to study the structure-activity relationships (SAR) of peptide hormones and receptor interactions.
• Metabolic Stability Studies: Employed in comparative studies to evaluate the impact of D-amino acid substitutions on peptide degradation and bioavailability.
• Process Development: Acts as a critical material in the scale-up and optimization of synthetic peptide manufacturing processes.
• Quality Control: Functions as a high-purity analytical reference standard for the identification and assay of related pharmaceutical compounds.

Basic Information

Product Name	(D-Ser4)-Histrelin
CAS No.	134053-51-3
Molecular Formula	C66H86N18O12
Molecular Weight	1323.5 g/mol
Synonyms	Histrelin (D-Ser4)-; [D-Ser4]-Histrelin; GnRH Agonist (D-Ser4) analog; LHRH Agonist analog; 5-Oxo-Pro-His-Trp-Ser-Tyr-D-Ser(But)-Leu-Arg-Pro-NHEt; Azaline B derivative; (D-Ser(tBu)4, Azagly10)-LHRH
EINECS	Contact for details

Quality Control

Our (D-Ser4)-Histrelin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure the correct stereochemistry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.