Description

(D-Ser4)-Gonadorelin is a synthetic analog of the hypothalamic decapeptide hormone Gonadotropin-Releasing Hormone (GnRH). This modified peptide is engineered for enhanced stability and specific receptor interaction, making it a critical tool in advanced endocrinology research and pharmaceutical development. It is primarily utilized by research institutions, diagnostic manufacturers, and biopharmaceutical companies engaged in reproductive health, neuroendocrinology, and peptide-based therapeutic discovery.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of GnRH receptor binding, signal transduction, and the hypothalamic-pituitary-gonadal axis.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutics for reproductive disorders and hormone-dependent conditions.
• Diagnostic Manufacturing: Employed in the production of immunoassay kits, calibration standards, and controls for measuring luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels.
• Structure-Activity Relationship (SAR) Studies: The D-Serine substitution at position 4 provides a model for investigating the effects of peptide backbone modification on metabolic stability and biological activity.
• Veterinary Science: Applied in research for animal fertility control and the management of reproductive cycles in livestock.

Basic Information

Product Name	(D-Ser4)-Gonadorelin
CAS No.	103065-82-3
Molecular Formula	C₅₅H₇₈N₁₈O₁₃
Molecular Weight	1183.33 g/mol
Synonyms	Des-Gly10-Gonadorelin Ethylamide; [D-Ser(tBu)4, des-Gly10]-GnRH Ethylamide; (D-Ser(tBu)⁴, des-Gly¹⁰)-LHRH Ethylamide; Gonadorelin (6-10) pentapeptide; GnRH analog; LHRH analog; Fertirelin acetate related compound; pGlu-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt
EINECS	Contact for details

Quality Control

Our (D-Ser4)-Gonadorelin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Acetate Content (HPLC)	5.0% - 12.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.