Description

(D-His2)-Leuprolide CAS NO 112642-11-2 is a synthetic peptide analog of naturally occurring gonadotropin-releasing hormone (GnRH), specifically engineered with a D-histidine substitution at the second position. This modification is critical for enhancing its metabolic stability and receptor binding affinity, making it a valuable tool in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies focused on endocrinology, oncology, and the development of novel therapeutic peptides and diagnostics.

Application

• Pharmaceutical Reference Standard: Serves as a critical high-purity standard for the quality control and analytical method development of leuprolide-based drug products.
• Endocrine Research: Used in preclinical studies to investigate the mechanisms of GnRH receptor interaction and the downstream effects on hormone secretion.
• Drug Discovery & Development: Acts as a key intermediate or analog in the R&D pipeline for novel peptide therapeutics targeting hormone-dependent conditions.
• Biochemical Assay Development: Employed in the development and validation of immunoassays, receptor binding assays, and other diagnostic tests.
• Metabolic Stability Studies: Utilized to study the impact of specific amino acid substitutions (like D-His) on the pharmacokinetic profile of peptide drugs.
• Academic Research: Supports fundamental research in universities and institutes studying peptide chemistry, neuroendocrinology, and molecular biology.

Basic Information

Product Name	(D-His2)-Leuprolide
CAS No.	112642-11-2
Molecular Formula	C₆₁H₈₈N₁₆O₁₂
Molecular Weight	1209.45 g/mol
Synonyms	Leuprolide (D-His2) analog; [D-His2]-Leuprolide; 5-Oxo-Pro-His-Trp-Ser-Tyr-D-His-Leu-Arg-Pro-NHEt; Leuprorelin (D-His2) derivative; GnRH agonist analog; LHRH agonist (D-His2) variant; pGlu-His-Trp-Ser-Tyr-D-His-Leu-Arg-Pro-NHEt
EINECS	Contact for details

Quality Control

Every batch of (D-His2)-Leuprolide is manufactured and analyzed under strict quality management systems. Our products undergo rigorous testing, including advanced chromatographic and spectroscopic methods, to ensure identity, purity, and consistency that meet the exacting standards for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.