Description

4-((1S)-1-Amino-2,2,2-Trifluoroethyl)Benzenecarbonitrile is a high-value, chiral trifluoromethylated building block essential for modern synthetic chemistry. This compound matters because it provides a versatile scaffold for introducing the metabolically stable trifluoromethyl group and a primary amine handle into complex molecules, enabling the development of novel bioactive compounds. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of advanced intermediates, particularly in the creation of potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of active pharmaceutical ingredients (APIs), especially in oncology, CNS, and metabolic disease areas.
• Agrochemical Synthesis: Used in the design and production of novel herbicides, fungicides, and insecticides that benefit from the properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Building block for specialty polymers and advanced organic materials with unique electronic or surface properties.
• Fluorine Chemistry Research: A critical compound for academic and industrial research exploring new methodologies in fluoroorganic chemistry.

Basic Information

Product Name	4-((1S)-1-Amino-2,2,2-Trifluoroethyl)Benzenecarbonitrile
CAS No.	943816-46-4
Molecular Formula	C9H7F3N2
Molecular Weight	200.16 g/mol
Synonyms	(S)-4-(1-Amino-2,2,2-trifluoroethyl)benzonitrile; (1S)-1-(4-Cyanophenyl)-2,2,2-trifluoroethanamine; Benzonitrile, 4-[(1S)-1-amino-2,2,2-trifluoroethyl]-; (S)-α-(Aminomethyl)-4-cyanobenzyltrifluoride; (S)-1-(4-Cyanophenyl)-2,2,2-trifluoroethylamine; (S)-4-(Aminomethyl)-α,α,α-trifluorotoluene-4-carbonitrile; (S)-ATFBCN
EINECS	Contact for details

Quality Control

Our 4-((1S)-1-Amino-2,2,2-Trifluoroethyl)Benzenecarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.