Description

(R)-De(Carboxymethoxy) Cetirizine Acetic Acid Hydrochloride is a high-purity pharmaceutical intermediate and chiral building block of significant importance in advanced organic synthesis. Its primary value lies in its role as a key precursor in the research and development of novel, enantiomerically pure antihistamines and related active pharmaceutical ingredients (APIs). This compound is essential for pharmaceutical R&D laboratories, process chemists, and manufacturers focused on developing next-generation therapeutics with improved efficacy and reduced side-effect profiles.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of enantiomerically pure cetirizine derivatives and related chiral drug candidates.
• Chiral Building Block: Used in asymmetric synthesis for constructing complex molecules with defined stereochemistry in medicinal chemistry programs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key starting material (KSM) or advanced intermediate in the route development and scale-up of new chemical entities (NCEs).
• Pharmacological Research: Employed in academic and industrial research to study structure-activity relationships (SAR) of histamine H1-receptor antagonists.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry & Optimization: Utilized for developing and optimizing robust, scalable synthetic pathways for commercial API manufacturing.

Basic Information

Product Name	(R)-De(Carboxymethoxy) Cetirizine Acetic Acid Hydrochloride
CAS No.	942132-30-1
Molecular Formula	C21H25ClN2O3 • HCl
Molecular Weight	425.35 g/mol (Free base: 388.89 g/mol)
Synonyms	(R)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid hydrochloride; (R)-De(carboxymethoxy)cetirizine HCl; (R)-Cetirizine descarboxymethoxy analog hydrochloride; (R)-L-Cetirizine intermediate; (R)-Ucb 28557 hydrochloride; (R)-P-Methylcetirizine precursor; (2R)-2-[2-[4-[(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl]ethoxy]acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-De(Carboxymethoxy) Cetirizine Acetic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical development. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming identity, purity, and impurity profiles. Our quality commitment aligns with ICH guidelines and supports regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.