Description

trans-Methyl 4-(3-Fluorophenyl)pyrrolidine-3-carboxylate is a high-purity, fluorinated pyrrolidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold that is essential for constructing complex molecules with targeted biological activity. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the development of new active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel central nervous system (CNS) active drugs, enzyme inhibitors, and receptor modulators.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing focused libraries in structure-activity relationship (SAR) studies and lead optimization programs.
• Agrochemical Synthesis: Serves as a precursor in the development of new generation herbicides, fungicides, and plant growth regulators that require fluorinated motifs for enhanced activity and stability.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Asymmetric Catalysis Ligand Precursor: Can be utilized to develop novel chiral ligands or organocatalysts for enantioselective synthesis.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring a specific, fluorinated pyrrolidine core structure.

Basic Information

Product Name	trans-Methyl 4-(3-Fluorophenyl)pyrrolidine-3-carboxylate
CAS No.	939758-19-7
Molecular Formula	C12H14FNO2
Molecular Weight	223.25 g/mol
Synonyms	Methyl (3R,4R)-4-(3-fluorophenyl)pyrrolidine-3-carboxylate; (3R,4R)-Methyl 4-(3-fluorophenyl)pyrrolidine-3-carboxylate; trans-4-(3-Fluorophenyl)-3-pyrrolidinecarboxylic acid methyl ester; 3-Carbomethoxy-4-(3-fluorophenyl)pyrrolidine; 939758-19-7; 4-(3-Fluorophenyl)pyrrolidine-3-carboxylic acid methyl ester, trans-
EINECS	Contact for details

Quality Control

Our trans-Methyl 4-(3-Fluorophenyl)pyrrolidine-3-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.