Description

1-(2,2-Difluoroethoxy)-4-Nitrobenzene is a specialized fluorinated aromatic nitro compound, serving as a valuable intermediate in advanced organic synthesis. Its molecular structure, featuring a difluoroethoxy side chain, makes it a critical building block for introducing fluorine-containing motifs into target molecules. This compound is primarily sought after by research institutions and chemical manufacturers engaged in the development of pharmaceuticals, agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates requiring fluorinated ether linkages to modulate bioavailability and metabolic stability.
• Agrochemical Research: Used in the development of next-generation herbicides, pesticides, and fungicides where the difluoroethoxy group can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Synthesis: Serves as a building block for fluorine-containing aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Organic Synthesis Reagent: Employed in cross-coupling reactions and nucleophilic aromatic substitutions to construct complex, fluorinated molecular architectures.
• Dye & Pigment Intermediate: Utilized in the production of specialized nitro-aromatic dyes and pigments where fluorine substitution alters color properties and lightfastness.
• Academic & Contract Research: A valuable reagent for methodological studies and discovery chemistry in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	1-(2,2-Difluoroethoxy)-4-Nitrobenzene
CAS No.	937599-94-5
Molecular Formula	C8H7F2NO3
Molecular Weight	203.14 g/mol
Synonyms	4-Nitro-1-(2,2-difluoroethoxy)benzene; p-Nitrophenyl 2,2-difluoroethyl ether; 2,2-Difluoroethyl 4-nitrophenyl ether; 1-(Difluoroethoxy)-4-nitrobenzene; 4-Nitrophenyl 2,2-difluoroethyl ether; NSC 876321; Benzene, 1-(2,2-difluoroethoxy)-4-nitro-
EINECS	Contact for details

Quality Control

Every batch of 1-(2,2-Difluoroethoxy)-4-Nitrobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.