Description

Benzonitrile, 5-5(Difluoromethyl)-2-Fluoro- is a high-purity, fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound is valued for its unique molecular scaffold, which introduces both fluorine atoms and a reactive nitrile group, enabling precise modifications in complex molecular architectures. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoromethyl and fluorine substituents can enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic applications, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The nitrile group and halogenated aromatic ring make it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to build complex biaryl systems.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution on molecular properties like lipophilicity, metabolic stability, and binding affinity in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical manufacturers and CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Benzonitrile, 5-5(Difluoromethyl)-2-Fluoro-
CAS No.	934175-58-3
Molecular Formula	C9H4F3N
Molecular Weight	183.13 g/mol
Synonyms	2-Fluoro-5-(difluoromethyl)benzonitrile; 5-(Difluoromethyl)-2-fluorobenzonitrile; 2-Fluoro-α,α-difluorotoluene-4-carbonitrile; Benzonitrile, 2-fluoro-5-(difluoromethyl)-; 4-Cyano-2-fluorobenzylidene difluoride
EINECS	Contact for details

Quality Control

Our production of Benzonitrile, 5-5(Difluoromethyl)-2-Fluoro- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We operate under a quality system designed to meet the rigorous standards required for pharmaceutical and advanced material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber glass, or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.