Description

2-Bromo-1,5-Difluoro-3-Iodobenzene is a highly functionalized halogenated benzene derivative, serving as a critical multi-halogen synthon in advanced organic synthesis. Its unique combination of bromine, fluorine, and iodine substituents on the aromatic ring makes it an exceptionally versatile building block for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Building Block: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials where specific halogen patterns are required for desired electronic properties.
• Cross-Coupling Reactions: Serves as an excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) due to the differential reactivity of the bromo and iodo groups.
• Fluorinated Compound Libraries: A valuable reagent for medicinal chemistry teams building diverse compound libraries to explore structure-activity relationships (SAR).
• Ligand and Catalyst Development: Used in the synthesis of complex, polydentate ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	2-Bromo-1,5-Difluoro-3-Iodobenzene
CAS No.	933585-14-9
Molecular Formula	C6H2BrF2I
Molecular Weight	318.89 g/mol
Synonyms	1-Bromo-3,5-difluoro-2-iodobenzene; 3,5-Difluoro-2-iodobromobenzene; Benzene, 2-bromo-1,5-difluoro-3-iodo-; 2-Iodo-1,5-difluoro-3-bromobenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-1,5-Difluoro-3-Iodobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.