Description

2,4-Difluoro-5-Nitrophenyl Propionate is a specialized fluorinated aromatic ester building block. This compound is valued for its unique molecular structure, which combines electron-withdrawing nitro and fluorine groups with a reactive ester linkage, making it a versatile intermediate in advanced synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex, fluorinated target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, where the difluoro-nitrophenyl moiety can contribute to biological activity.
• Material Science Research: Serves as a precursor for specialty polymers and advanced organic materials that incorporate fluorinated aromatic units for enhanced performance properties.
• Chemical Biology Probes: Employed in the synthesis of fluorinated probes and tags for studying biological systems and diagnostic applications.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluorine groups make it suitable for selective substitution reactions to introduce diverse functionalities.

Basic Information

Product Name	2,4-Difluoro-5-Nitrophenyl Propionate
CAS No.	924868-80-4
Molecular Formula	C9H7F2NO4
Molecular Weight	231.15 g/mol
Synonyms	Propanoic acid, 2,4-difluoro-5-nitrophenyl ester; 5-Nitro-2,4-difluorophenyl propionate; 2,4-Difluoro-5-nitrophenyl propanoate; 924868-80-4; 2,4-Difluoro-5-nitro-1-propionyloxybenzene
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-5-Nitrophenyl Propionate is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.