Description

2-Chloro-3,4-Difluorobenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for selective functionalization and incorporation into complex molecular architectures. This high-purity intermediate is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and chloro substituents contribute to biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for creating specialized fluorinated aromatic compounds used in electronic display technologies.
• Organic Ligand Synthesis: Employed in the preparation of complex ligands for catalysis and material science applications.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D exploring new fluorinated heterocycles and functional materials.

Basic Information

Product Name	2-Chloro-3,4-Difluorobenzonitrile
CAS No.	924626-68-6
Molecular Formula	C7H2ClF2N
Molecular Weight	173.55 g/mol
Synonyms	2-Chloro-3,4-difluorobenzonitrile; 3,4-Difluoro-2-chlorobenzonitrile; Benzonitrile, 2-chloro-3,4-difluoro-; 2-Chloro-3,4-difluorophenyl cyanide; 924626-68-6; 2-Cl-3,4-F2-BnCN
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,4-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.